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鹽酸益母草堿 |
| CAS No.: |
24697-74-3 |
| 分子式： |
C14H21O5N3.HCl.H2O |
| 分子量： |
365.81 |
| 備注： |
中文名稱鹽酸益母草堿中文同義詞益母草堿鹽酸鹽,益母草堿;鹽酸益母草堿(益母草堿鹽酸鹽,益母草堿);LEONURINEHYDROCHLORIDE鹽酸益母草堿;鹽酸益母草堿(3,5-二甲氧基-4-羥基-苯甲酸(4-胍基)-1-丁酯一水合物鹽酸鹽);鹽酸益母草堿;3,5-二甲氧基-4-羥基-苯甲酸(4-胍基)-1-丁酯一水合物鹽酸鹽;益母草堿鹽酸鹽;鹽酸益母草堿(標(biāo)準(zhǔn)品)英文名稱Leonurinehydrochloride英文同義詞Leonurine4-Guanidino-1-butanolsyringate;SCM-198;leonurinehydrochloride;4-Guanidino-1-butanolsyringate;4-(diaminomethylideneamino)butyl4-hydroxy-3,5-dimethoxy-benzoatehydrochloride;Leonurine;LEONURINEHCL;4-Hydroxy-3,5-dimethoxybenzoicacid4-guanidinobutylesterCAS號(hào)24697-74-3分子式C14H21N3O5分子量311.33EINECS號(hào)683-174-6植物來源益母草相關(guān)類別中草藥成分;中藥對(duì)照品;標(biāo)準(zhǔn)品;對(duì)照品,標(biāo)準(zhǔn)品;植物提取物;合成;對(duì)照品;植提標(biāo)準(zhǔn)品;醫(yī)藥原料藥;標(biāo)準(zhǔn)品-對(duì)照品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;對(duì)照品-中藥對(duì)照品;生物堿;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品，對(duì)照品;原料;醫(yī)藥化工類Mol文件24697-74-3.mol結(jié)構(gòu)式鹽酸益母草堿性質(zhì)熔點(diǎn)238°C沸點(diǎn)496.7±55.0°C(Predicted)密度1.29±0.1g/cm3(Predicted)儲(chǔ)存條件Keepindarkplace,Inertatmosphere,2-8°C溶解度DMSO：可溶，2mg/mL，澄清（加熱）酸度系數(shù)(pKa)8.26±0.25(Predicted)形態(tài)粉末顏色白色至米色穩(wěn)定性可在-20°C下的DMSO溶液保存長達(dá)1個(gè)月。InChIKeyWNGSUWLDMZFYNZ-UHFFFAOYSA-N鹽酸益母草堿用途與合成方法生物活性Leonurine是從Herbaleonuri中分離到的生物堿，具有抗氧化、抗炎活性。體外研究Leonurine(0,5,10,20,40,80μM)causesdiminutioninlipidaccumulation,cellularcholesterolcontent,includingtotalcholesterol(TC),freecholesterol(FC)andcholesterylester(CE),andincreaseinapoA-I-orHDL-meChemicalbookdiatedcholesteroleffluxaftertreatmentfor24h.Leonurinealsosignificantlyanddose-dependentlyincreasestheexpressionsofABCA1andABCG1atthemRNAandproteinlevelsinhumanTHP-1macrophages,andsucheffectisinvolvedinPPARγ.Leonurinehydrochloride(LH)showsprotectiveeffectoncellviabilityofHepG2andHL-7702cellsincubatedwithpalmiticacid(PA)offreefattyacid(FFA)for24h.Leonurinehydrochloride(125,250,500μM)improvescellularlipidaccumulationinHepG2andHL-7702cellsviaactivatingAMPK/SREBP1pathway.Leonurine(5,10,20μM)inhibitstheexpressionofiNOS,COX-2,PGE2,NO,TNF-α,andIL-6inIL-1β-inducedhumanchondrocytes,suppressesECMdegradationinhumanOAchondrocytes,andblocksIL-1β-inducedPI3KandAktphosphorylationinadose-dependentmanner.體內(nèi)研究Leonurine(10mg/kg/d,p.o.)significantlyincreasestheexpressionsofPPARγ,LXRα,ABCA1andABCG1,anddecreasesbothTGandTClevelsinserumofmice.Leonurinehydrochloride(50,100,200mg/kg)improvesintracellularlipidaccumulationviaactivatingAMPK/SREBP1pathway,enhancesbiochemicalparameters,reduceshepaticlipoperoxideandincreasesantioxidantlevelsinmice.Leonurine(20mg/kg,p.o.)amelioratesosteoarthritisdevelopmentinmouseDMMmodel.化學(xué)性質(zhì)白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于益母草。用途益母草堿具有活血、祛淤、調(diào)經(jīng)、消水的作用。用途用于含量測定/鑒定/藥理實(shí)驗(yàn)等藥理藥效:1．對(duì)子宮的作用益母草堿對(duì)兔、貓、犬、豚鼠等多種動(dòng)物的子宮均呈興奮作用2．對(duì)循環(huán)系統(tǒng)的作用小劑量益母草堿對(duì)離體蛙心有增強(qiáng)收縮作用，使用大量時(shí)反呈抑制現(xiàn)象。這種抑制現(xiàn)象可能由于迷走神經(jīng)末梢興奮所致。 |
| 結(jié)構(gòu)式： |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開發(fā)區(qū)光谷大道03號(hào) |
郵 編： |
430000 |
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18995560451 |
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